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Regrow Your Hair, Starting Now
A New Science Now series from New Health & Longevity and Apple Poly LLC
The Current Science on the
Hair Growth Promoting Effects of Procyanidins
In
1999, a group of scientists at Tsukuba Research Laboratories in Ibaraki,
Japan published the first studies showing hair growth promoting effects
of procyanidin chemicals extracted from apples. Since these first reports
were published, multiple studies in cells, animals and human clinical
trials have confirmed the effectiveness of procyanidins to intensively and
safely promote hair growth.
Click on
the titles below for a more in-depth review of the science
behind these safe natural plant phytochemicals for hair growth.
| 1999 |
Takahashi T, Kamiya T, Hasegawa A,
Yokoo Y.
Procyanidin oligomers selectively and intensively promote
proliferation of mouse hair epithelial cells in vitro and activate
hair follicle growth in vivo.
J Invest Dermatol. 1999 Mar;112(3):310-6. |
Takahashi T, Yokoo Y, Inoue T, Ishii
A.
Toxicological studies on procyanidin B-2 for external application
as a hair growing agent.
Food Chem Toxicol. 1999 May;37(5):545-52. |
| 2000 |
Takahashi T, Kamimura A, Shirai A,
Yokoo Y.
Several selective protein kinase C inhibitors including
procyanidins promote hair growth.
Skin Pharmacol Appl Skin Physiol. 2000
May-Aug;13(3-4):133-42. |
Kamimura A, Takahashi T, Watanabe Y.
Investigation of topical application of procyanidin B-2 from apple
to identify its potential use as a hair growing agent.
Phytomedicine. 2000 Dec;7(6):529-36. |
Takahashi T, Kamimura A, Yokoo Y.
Hair-Growing Activity of Procyanidins.
Journal of SCCJ; 2000 34(3):273-282. |
Kamimura A, Takahashi T
Advanced research on hair growth mechanism and development of hair
growers. The hair-growing activity of procyanidins.
Fragr J 2000
;28(2):27-32 |
| 2001 |
Takahashi T.
Biological actions of oligomeric procyanidins: proliferation of
epithelial cells and hair follicle growth.
Methods Enzymol. 2001;335:361-8. No abstract available. |
Takahashi T, Kamimura A, Yokoo Y,
Honda S, Watanabe Y.
The first clinical trial of topical application of procyanidin B-2
to investigate its potential as a hair growing agent.
Phytother Res. 2001 Jun;15(4):331-6. |
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T Takahashi, A Kamimura, S Honda, M
Kagoura, M Ohtsuyama, M Morohashi.
The Hair-Growing Activity of Procyanidin Oligomers
European Hair Research
Society, Tokyo 2001 |
| 2002 |
Kamimura A, Takahashi T.
Procyanidin B-2, extracted from apples, promotes hair growth: a
laboratory study.
Br J Dermatol. 2002 Jan;146(1):41-51. |
Takahashi T, Kamimura A,
Kobayashi A, Hamazono T, Yokoo Y, Honda S, Watanabe Y
Hair-Growing Activity of Procyanidin B-2
Journal of Japanese Cosmetic Science Society, 26(4):225-233 |
Kamimura A, Takahashi T.
Procyanidin B-3, isolated from barley and identified as a
hair-growth stimulant, has the potential to counteract inhibitory
regulation by TGF-beta1.
Exp Dermatol. 2002 Dec;11(6):532-41. |
| 2005 |
Takahashi T, Kamimura A, Kagoura M,
Toyoda M, Morohashi M.
Investigation of the topical application of procyanidin oligomers
from apples to identify their potential use as a hair-growing agent.
J Cosmet Dermatol. 2005 Dec;4(4):245-9. |
| 2006 |
Kamimura A, Takahashi T, Morohashi M,
Takano Y.
Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced
apoptosis in hair epithelial cells: an insight into their mechanisms.
Skin Pharmacol Physiol. 2006;19(5):259-65. Epub 2006
Jun 16. |
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| Related Compounds |
Takahashi T, Kamiya T, Yokoo Y.
Proanthocyanidins from grape seeds promote proliferation of mouse
hair follicle cells in vitro and convert hair cycle in vivo.
Acta Derm Venereol. 1998 Nov;78(6):428-32. |
Towatari K, Yoshida K, Mori N, Shimizu
K, Kondo R, Sakai K.
Polyphenols from the heartwood of Cercidiphyllum japonicum and
their effects on proliferation of mouse hair epithelial cells.
Planta Med. 2002 Nov;68(11):995-8. |
A careful review of
this material leaves little doubt that procyanidins from apples strongly
promote hair growth. I urge you to consider putting these safe, effective
compounds to work to slow, stabilize, and even reverse your unwanted hair
loss. You are losing valuable time.
Procyanidin therapy is available now.
New
user reports are now online.
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