Research

There is a vast and growing body of research into the effects of apple polyphenol consumption on human health.

This research takes place at some of the world’s top universities. And is published in major scientific and medical journals. Many of the findings astonish the researchers themselves. Yet most of us never hear about it.

Our mission is to change that. On this page, we clarify the most important apple polyphenol research for people who want to take control of their health.

Click on the health outcome you are interested in below. Then, you can review the actual scientific studies, with our commentary about what the researchers discovered.

Check back often––we are continually adding to this page as new research is published!
 

Clinically studied at:

Latest

July 18, 2025

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial

A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia

Browse by Benefit

Regrow hair

Reduce body fat

Enhance blood flow

Activate anti-inflammatory genes

Protect skin from ultraviolet rays

Restore metabolic and digestive health

Lower oxidized cholesterol

Regulate blood sugar

Third-party Tested

Apple Poly® is Kosher certified and USDA tested for your peace of mind.

Meet the Polyphenols

Apple Poly contains 30+ bioactive polyphenols gently extracted from the skins of baby green (unripe) apple skins, where the polyphenols are most highly concentrated.

Some of the most potent and clinically studied polyphenols in our formula are:

Phloridzin Procyanidin B2 Procyanidin C1 Epicatechin Chlorogenic Acid

Phloridzin is a polyphenol found almost exclusively in apple root, bark, stems, and peels that helps control blood sugar. Apple Poly is the only product with standardized amounts of phloridzin, which works by slowing down how much glucose your body absorbs from food and how much your kidneys reabsorb, helping to keep your blood sugar levels steady after meals. (Which is important, because blood sugar spikes can greatly damage the body.) It also has anti-inflammatory benefits, particularly in the gut, and can help balance the bacteria in your digestive system.

Procyanidin B2 is a polyphenol (most highly concentrated in apple skins) that helps protect your body from oxidative stress that damages cells and tissues. It plays a key role in protecting your heart and blood vessels by reducing harmful fats in the blood. This polyphenol also supports healthy skin by promoting collagen production and protecting against UV damage. In clinical studies, Procyanidin B2 has shown promise in stimulating hair regrowth by boosting the activity of hair follicles, making it a powerful natural aid for reversing hair loss.

Procyanidin C1 is a polyphenol that helps your body clear away damaged or aging cells, known as senescent cells. These cells can accumulate over time and contribute to aging and disease, but Procyanidin C1 helps remove them, allowing healthier cells to thrive. It also boosts your body’s natural repair mechanisms, supporting DNA repair and enhancing the function of your immune system. By clearing out these old cells and promoting overall cellular health, Procyanidin C1 may play a role in slowing the aging process.

Epicatechin is a polyphenol with powerful vascular benefits, particularly its ability to stimulate nitric oxide production. This promotes vasodilation, improving blood flow and reducing blood pressure. It has also been linked to enhanced muscle function and endurance by increasing mitochondrial biogenesis and improving blood supply to muscle tissues. In addition, epicatechin contributes to brain health by crossing the blood-brain barrier and supporting neuroplasticity, potentially aiding memory and cognition.

Chlorogenic acid is a compound in apples that helps control blood sugar by slowing down how much glucose your liver produces. It’s also anti-inflammatory and can reduce stress in your gut, improving your digestion and gut health. Chlorogenic acid may also help with weight loss by influencing how your body stores and burns fat.