Research
Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation
There is no treatment currently available to prevent or retard chemotherapy-induced alopecia. This paper shows how apple polyphenols can preserve hair and pr...
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Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth?
Eight out of nine critical hair growth pathways—unlocked by one compound? There’s simply no other hair growth solution—natural or synthetic—that activates th...
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Do Non-Prescription Products Help in Managing Androgenic Alopecia?
Apple-derived procyanidin B2 therapy emerges here as the class of the field in natural hair growth options, with rigorous clinical trials and clear results i...
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The Effect of Apple (Malus sylvestris mill) as a Natural Ingredient to Prevent Hair Loss
This review study from Indonesia highlights evidence from human clinical trials, showing measurable hair regrowth in subjects with alopecia treated with appl...
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An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice
After three-week treatment with procyanidin-rich apple extract, hair length, weight, thickness, and density showed significant increases in both low and high...
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Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation
This study fills a critical gap in understanding how polyphenol-rich apple extracts stimulate hair growth at the cellular level.
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Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial
“We observed significant results in terms of increased hair growth, density, and keratin content, already after 2 months.” This is the first human clinical t...
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A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia
This randomized, double-blind, placebo-controlled trial offers further clinical proof that oral apple polyphenols can slow hair loss and accelerate hair grow...
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Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells
This study adds a unique layer to the growing body of research on apple polyphenols and hair growth. While many nutraceuticals claim benefits, apple procyani...
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Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss
This well-referenced Italian study on apple polyphenols tops out at 47 citations, spanning hair biology, polyphenol analytics, clinical trials, extraction me...
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Apple Juice Phenolics Inhibit Human LDL Oxidation
This paper stands as an early mechanistic insight into how everyday foods—like polyphenol-rich apple juice—can defend against oxidative damage tied to heart ...
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Plant polyphenols as dietary antioxidants
If a new wonder drug could target 4 of the 5 leading causes of death, would you take it?
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The influence of different forms of apple products on all-cause mortality in patients with hypertension
Eating whole apples 3–6 times per week was linked to a 48% drop in death risk for hypertensive patients, highlighting the power of polyphenols in the peels.
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Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease:
From the authors: “An improvement in vascular function was only seen after the high-flavonoid apple treatment... attributable to the high concentration of fl...
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Skin Moisturizing Activity of Unripe Apple (Immature Fruit of Malus pumila) in Mice
This study adds to a growing body of evidence supporting polyphenol-rich fruit extracts as bioactive agents for skin health. It complements prior research on...
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Dietary polyphenols, metabolic syndrome and cardiometabolic risk factors:
This 2023 study tracked real-life eating habits over a full year in 676 adults, offering meaningful insight into habitual polyphenol consumption. Those with ...
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Association of flavonoids and flavonoid-rich foods with all-cause mortality:
In this 14 year follow-up study in older Australians, high proanthocyanidin intake brought mortality risk down nearly 31%. In those with early mortality risk...
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Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes
"In the present study, we searched for phytochemicals from natural sources that possess significant anti-aging effects, and made further studies of the mecha...
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ANTI-AGING EFFECTS OF APPLE PROCYANIDINS
"These findings strongly indicate that APs showed anti-aging effects, such as anti-oxidative, anti-protein aggregation and pro-longevity effects, using model...
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The effects and associations of whole-apple intake on diverse cardiovascular risk factors:
“Whole-apple intake improves different CVD risk factors through the reduction of blood pressure, pulse pressure, total cholesterol, low-density lipoprotein c...
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Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties:
"What is now proved was once only imagined." — William Blake Researchers from India, Czech Republic, and the UK propose fruit polyphenols as dietary compoun...
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