Research
Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation
This study fills a critical gap in understanding how polyphenol-rich apple extracts stimulate hair growth at the cellular level.
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Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial
“We observed significant results in terms of increased hair growth, density, and keratin content, already after 2 months.” This is the first human clinical t...
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A randomized double-blind placebo-controlled clinical trial to evaluate the effect of an Annurca apple supplement formula in androgenic alopecia
This randomized, double-blind, placebo-controlled trial offers further clinical proof that oral apple polyphenols can slow hair loss and accelerate hair grow...
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Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells
This study adds a unique layer to the growing body of research on apple polyphenols and hair growth. While many nutraceuticals claim benefits, apple procyani...
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Malus pumila Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss
This well-referenced Italian study on apple polyphenols tops out at 47 citations, spanning hair biology, polyphenol analytics, clinical trials, extraction me...
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Apple Juice Phenolics Inhibit Human LDL Oxidation
This paper stands as an early mechanistic insight into how everyday foods—like polyphenol-rich apple juice—can defend against oxidative damage tied to heart ...
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Plant polyphenols as dietary antioxidants
If a new wonder drug could target 4 of the 5 leading causes of death, would you take it?
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The influence of different forms of apple products on all-cause mortality in patients with hypertension
Eating whole apples 3–6 times per week was linked to a 48% drop in death risk for hypertensive patients, highlighting the power of polyphenols in the peels.
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Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease:
From the authors: “An improvement in vascular function was only seen after the high-flavonoid apple treatment... attributable to the high concentration of fl...
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Skin Moisturizing Activity of Unripe Apple (Immature Fruit of Malus pumila) in Mice
This study adds to a growing body of evidence supporting polyphenol-rich fruit extracts as bioactive agents for skin health. It complements prior research on...
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Dietary polyphenols, metabolic syndrome and cardiometabolic risk factors:
This 2023 study tracked real-life eating habits over a full year in 676 adults, offering meaningful insight into habitual polyphenol consumption. Those with ...
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Association of flavonoids and flavonoid-rich foods with all-cause mortality:
In this 14 year follow-up study in older Australians, high proanthocyanidin intake brought mortality risk down nearly 31%. In those with early mortality risk...
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Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes
"In the present study, we searched for phytochemicals from natural sources that possess significant anti-aging effects, and made further studies of the mecha...
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ANTI-AGING EFFECTS OF APPLE PROCYANIDINS
"These findings strongly indicate that APs showed anti-aging effects, such as anti-oxidative, anti-protein aggregation and pro-longevity effects, using model...
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The effects and associations of whole-apple intake on diverse cardiovascular risk factors:
“Whole-apple intake improves different CVD risk factors through the reduction of blood pressure, pulse pressure, total cholesterol, low-density lipoprotein c...
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Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties:
"What is now proved was once only imagined." — William Blake Researchers from India, Czech Republic, and the UK propose fruit polyphenols as dietary compoun...
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Polyphenols of Apples and Their Potential Health Benefits
This chapter remains a go-to primer for understanding the wide ranging biological effects of apple polyphenols, and a prequel to more targeted studies on UV ...
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Fruits and Herbs as Potential Human Anti-Aging Compounds – A Review
“These results clearly suggest that, when applied to model organisms, APs demonstrated anti-aging properties, including anti-oxidative, anti-protein aggregat...
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Effectiveness of Dietary Supplement for Skin Moisturizing in Healthy Adults:
“This is the first meta-analysis to evaluate the effectiveness of oral dietary supplements for skin moisturizing in healthy adults.”
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A deep dive into the orchard of health:
“This review highlights the emerging role of apple polyphenols as multifunctional agents in the maintenance of physiological balance and healthy aging.”
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Evaluation of Safety of Excessive Intake and Efficacy of Long-term Intake of Beverages Containing Apple Polyphenols
In this 12 week randomized, controlled clinical trial, abdominal fat, waist and hip circumference, waist-to-hip ratio, and BMI all decreased significantly co...
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