Visceral Fat-Reducing Effect of Supplement Containing Apple Polyphenol and Oleanolic Acid in Healthy Japanese:

A Randomized, Double-Blind, Placebo-Controlled Study

Publication Date:
2016-03-01

Institutions involved:

JACTA (Japan Clinical Trial Association)
Nihonbashi M’s Clinic
GRACEAS Corporation

Participants:
29 healthy Japanese women aged 20–59, BMI ≤ 30

Duration:
12 Weeks

Dosage:
600 mg daily

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Key Takeaways:

Clinically Proven Fat Reduction: 600 mg tablets delivered a statistically significant decrease in abdominal fat, including 6 lbs of verified weight loss over 12 weeks.

Enhanced Well-Being:
8 of 9 quality-of-life markers improved, including sleep, mood, energy, and “feeling lighter”— whole-body benefits beyond fat loss.

Weight loss without dieting:
Subjects followed normal daily routines—no exercise or diet adjustments required—yet still saw reductions in weight, BMI, and waist size.

Apple Poly Summary:

Why is this study important? This randomized, double-blind, placebo-controlled trial evaluated the effects of a supplement containing apple polyphenols and oleanolic acid on visceral fat in healthy Japanese adults. The findings showed significant reductions in visceral fat, body weight, BMI, and waist circumference after 12 weeks—highlighting the potential of this combination as a safe, food-based strategy for managing abdominal obesity.

In Plain English: In this study, people took a supplement made from apples and a plant compound called oleanolic acid every day for 12 weeks. By the end, they had less belly fat, lost weight, and trimmed their waistlines—without changing their diet or exercise. The results suggest that this natural combo might help people manage stubborn fat around their organs.

For Medical Professionals: This 12-week RCT assessed the efficacy of a supplement (CUTTO tablet) containing apple polyphenols and oleanolic acid in reducing visceral adiposity among healthy Japanese adults. Among 29 evaluable participants, the treatment group showed statistically significant reductions in visceral fat area (via CT), body weight, BMI, and waist circumference compared to placebo. Subjective improvements in 8 of 9 questionnaire items were also observed. The findings support the use of polyphenol–triterpenoid synergy in modulating central adiposity and metabolic risk markers in non-obese populations.

Abstract:

Objectives: The objective of this research was to investigate the effectiveness of daily ingestion of a CUTTO tablet, which contains apple polyphenol and oleanolic acid on weight reduction and waist circumference reduction.

Methods: In this randomized, placebo-controlled, double-blind trial, 40 subjects were randomized. To evaluate this objective, visceral fat area and subcutaneous fat area were measured as the primary outcome. Weight, BMI, waist circumference and subjective reporting was also observed as the primary outcome.

Results: 3 subjects were withdrawn due to personal reasons and 8 subjects were excluded from efficacy analysis due to taking a meal before getting a CT scan and sending in adequate records. With 29 subjects, the visceral fat area of CUTTO decreased significantly compared with Placebo after 12 weeks of ingestion. Furthermore, significant difference was observed between the two groups in weight, BMI and waist circumference after 12 weeks. Moreover, 8 items out of 9 showed significant difference with results from a questionnaire, in the intergroup comparison of 12-week ingestion.

Conclusion: The present results suggest that daily ingestion of CUTTO tablets including apple polyphenol and oleanolic acid can reduce weight and waist circumference.